Senior Medical Science Liaison (Senior MSL)

The Opportunity

Praxis is seeking a field-based Senior Medical Science Liaison (Senior MSL) to support Medical Affairs activities for ulixacaltimide during prelaunch and potential launch. This role is focused on building trusted scientific partnerships, delivering high-quality scientific exchange, and generating actionable insights to inform medical strategy and ensure clinical readiness. You will provide coaching, guidance, and peer leadership to other MSLs while also maintaining strategic engagement with key investigators, movement disorder specialists, and other neurology stakeholders.

This individual will play a critical role in translating medical strategy into field execution, ensuring high-quality scientific exchange, and driving clinical and account readiness in advance of and following potential approval. The role requires strategic thinking and field engagement, serving as a field-based scientific leader and trusted resource to the broader MSL team.

Given the significant unmet need in essential tremor and the opportunity to introduce a novel therapeutic option, this role will help shape disease education, stakeholder engagement, and the evolving treatment paradigm across both academic and community neurology settings.

Success in this role requires strong clinical credibility, excellent communication skills, strategic thinking, and comfort operating autonomously in a fast-paced environment.

Primary Responsibilities

Field Strategy & Execution

• Translate medical strategy into a clear, executable field plan aligned with pre-launch and launch priorities
• Contribute to territory planning, KOL identification, and stakeholder engagement strategies across regions
• Ensure consistent, high-quality scientific exchange across the team, including disease state education and product data communication
• Support clinical and account readiness efforts, including site preparedness, patient identification, and integration into clinical practice
• Monitor field activity and adapt strategy based on evolving insights and market dynamics
• Support territory alignment and resource deployment strategies to ensure optimal coverage of key accounts and stakeholders
• Support the evolution of field medical strategy across the product lifecycle, from pre-launch readiness through post-launch adoption and expansion

KOL Engagement & Scientific Leadership

• Maintain direct relationships with key national and regional KOLs, investigators, and thought leaders
• Lead high-impact scientific engagements, including advisory boards, congress interactions, and complex clinical discussions
• Serve as a scientific leader within the organization, ensuring credibility and consistency in external interactions
• Support the identification and development of emerging influencers and strategic partnerships

Insight Generation & Cross-Functional Collaboration

• Oversee the collection, synthesis, and communication of field insights to inform medical and cross-functional strategy
• Partner closely with Clinical Development, Commercial, and Market Access to ensure alignment and effective execution
• Translate field insights into actionable recommendations that shape launch strategy, evidence generation, and stakeholder engagement
• Contribute to the development of medical materials, training, and strategic initiatives as needed
• Represent the voice of the external medical community by translating field insights into strategic recommendations that inform medical and cross-functional decision-making

Qualifications and Key Success Factors

• Advanced clinical or scientific degree (PharmD, PhD, MD, NP, PA, or RN)
• Experience in medical affairs, clinical research, clinical care, or field-based roles within biotech/pharma
• Demonstrated ability to interpret, communicate, and translate complex scientific and clinical data into clear, actionable insights for diverse stakeholders
• Strong ownership mindset with the ability to operate independently, navigate ambiguity, and drive impact in a dynamic pre-launch/launch environment
• Proven ability to build and maintain trusted relationships with healthcare professionals, including investigators and key opinion leaders
• Experience gathering, synthesizing, and translating field insights into actionable recommendations for cross-functional teams
• Ability to manage multiple priorities with strong organizational skills, attention to detail, and consistent follow-through
• Willingness and ability to travel extensively (60–80%) in a field-based role
• Demonstrated experience leading, coaching field-based teams
• Proven ability to translate medical strategy into effective field execution and operational plans
• Experience influencing cross-functional stakeholders and aligning teams in a matrixed environment
• Experience in neurology, CNS disorders or movement disorders is preferred
• Experience within market access/payor landscape is preferred
• Demonstrated ability to rapidly develop expertise in new therapeutic areas and apply insights to field strategy
• Candidates with prior field-based experience and a demonstrated track record of independently driving scientific engagement, shaping clinical perspectives, and contributing to successful pre-launch and launch activities will be considered at a higher level

The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. You'll need comfort with screen work, basic hand coordination, and focus. Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.